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Anti-reflux

Chronic acid reflux and hiatal hernia are conditions where stomach acid escapes into the oesophagus, leading to discomfort, but can often be resolved through minimally invasive surgical techniques.

What is gastro-oesophageal reflux disease (GORD)?

This is a condition where stomach acid travels backwards from the stomach into your gullet (oesophagus). It is a normal occurrence in everyone, but we all have mechanisms to reduce the effect of it. If these are faulty, it can cause reflux disease, and there are two main types.

Primary GORD

The muscle valve between the stomach and gullet (oesophagus), which normally allows food to pass into the stomach, can become weak or relax inappropriately and let too much acid up into the gullet. The normal gullet would squeeze this back into the stomach, but this can become impaired and the acid has its symptomatic effect.

Risk factors for this include:
  • Living with overweight or obesity – places pressure on the stomach and weakens the valve (sphincter).
  • Pregnancy – temporarily increases pressure on the stomach, and hormone changes can affect the muscle of the valve.
  • Smoking, coffee or alcohol – causes inappropriate relaxation of the valve, or damages the tissues themselves.
  • Small hiatus hernia – the junction of the gullet and stomach has moved upwards through the diaphragm.
  • Delayed stomach emptying, caused by other medical conditions like diabetes, or related to the side effects of medicines or smoking.

A hiatus hernia

This is a condition where part of the stomach, not just the position of the gastro-oesophageal junction (GO-junction), migrates through the opening in the diaphragm (hiatus) into the chest. There are several types:

  • I – Sliding (the commonest): the GO-junction and small part of the top of the stomach moves upwards through the diaphragm opening - similar to primary GORD.
  • II – Rolling (rarer): the GO-junction appears at the correct level but a small part of the top of the stomach moves upwards through the diaphragm opening.
  • III – Paraoesophageal: a significant portion of the stomach (20–100%) moves upwards through the diaphragm opening and into the chest.
  • IV – Giant paraoesophageal: the whole stomach and other organs move upwards through the diaphragm opening and into the chest.

What causes a hiatus hernia?

Many of the risk factors for primary GORD also lead to a hiatus hernia over longer periods of time. Older age is a significant factor, as muscles weaken, and most large hiatus hernias occur in patients over 60. A few hiatal and diaphragm hernias are congenital and occur after birth, but Mr Hopkins does not treat childhood conditions.

What symptoms does GORD or a hiatus hernia cause?

Common
  • Heartburn – a burning sensation in the chest behind the breastbone. Typical GORD symptoms are worse after eating larger meals or on lying flat or bending over. Trigger foods do not usually cause these.
  • Regurgitation – food itself can return into the oesophagus or even into the mouth or nose.
Less common
  • Cough – particularly at night
  • Chest sensitivity
  • Recurrent chest infections
  • Rarely, bad breath or tooth decay

Other problems that may be related must be investigated urgently and separately:

  • Chest pain – should prompt review of the heart or circulation first
  • Voice changes – should always be investigated by an ENT surgeon first
  • Difficulty swallowing – should be assessed by your GP for a ‘2-week wait referral’ cause
  • Breathing difficulty – should be seen by a respiratory doctor and checked out
  • Anaemia – requires tests for blood loss elsewhere in the intestine, urine, or genitals

How are GORD or a Hiatus Hernia Diagnosed?

Mr Hopkins will review your symptoms in detail in clinic and the diagnosis is normally made on the basis of your symptoms. If there are any doubts about your symptoms, they are persistent or unusual, where medications do not work, and always where surgery is being considered, you will be referred for further tests - these include:

Upper GI endoscopy or OGD

This is the procedure where a telescope is passed via the mouth to examine the gullet (oesophagus), stomach, and duodenum.

Why might I need an upper GI endoscopy?

It is recommended to fully assess your hiatal anatomy and to fully investigate GORD-related symptoms such as:

  • Difficulty swallowing (dysphagia)
  • Acid reflux
  • Persistent nausea and vomiting
  • Vomiting blood
  • Unexplained weight loss
How do I prepare for the endoscopy?

You must not eat or drink for at least 4 hours before the procedure, although you may drink a small cup of water up to 2 hours before the test. You should take your regular prescription medications, unless you are otherwise advised by Mr Hopkins to stop any specifically for the test.

Can I have throat spray and/or sedation?

The test is normally carried out while you are conscious, using throat spray (local anaesthetic to numb the back of your throat—like at the dentist) or sometimes with a sedative injection to make you slightly drowsy. Most patients tolerate it with throat spray alone, allowing a quicker recovery and return to normal after the test. If you do have a sedative, you cannot drive, work or operate machinery for 24 hours and you would need someone to take you home and stay with you overnight. Sedation is not a full general anaesthtic, which is rarely required unless you are having a more complicated therapeutic endoscopy.

What happens during the endoscopy?

After the throat spray, you will be positioned comfortably on your left side and a small mouthguard placed to protect your teeth. Any sedation requested will be given, and once you are ready, the small telescope will be passed through your mouth and through your throat and into the gullet. It does not interfere with breathing, and any saliva that collects in your mouth is removed by the nurse using a sucker.

During the procedure, small amounts of gas are used to inflate the areas, and sometimes a tissue sample (biopsy) may be taken for laboratory examination.

What happens after the endoscopy?

The test normally takes between 3–5 minutes. After throat spray, you cannot eat or drink for one hour, as the local anaesthetic temporarily affects your swallowing. If you have sedation, a friend or relative should collect you and ideally stay with you overnight. Mr Hopkins will discuss the results with you immediately after the test, will provide a written report for you, and a copy will also be sent to your own GP.

Are there any risks?

Everyone experiences a short-term sore throat, but complications are very uncommon following diagnostic endoscopy (less than 1 in 1000). Rarely, these include bleeding, perforation or a reaction to the drugs given.

Other specialist diagnostic tests

High-resolution manometry

A thin tube is passed into your gullet via the nose, and a series of pressure measurements are made while you swallow small sips of a drink. This is very safe, and your breathing is not affected by the tube, although patients can feel some discomfort in the throat during the 10-minute test. This test measures how well the muscles in your gullet are working, and Mr Hopkins will interpret the results from the physiology team in a follow-up clinic with you.

24-hour pH / impedance studies

Again, a thin tube is placed via the nose into your gullet, where it can stay for 24–72 hours, while you eat, drink, and carry on normally. Your breathing will not be affected during the procedure, and it may be a little uncomfortable rather than painful on insertion, but this will settle quickly. The tube will be taped to the outside of your nose, passed around your ear and attached to a small recording box which is worn on a shoulder strap or belt around your waist, which will also record your symptoms when you press a button. You will be able to eat, sleep, and carry on normal daily routines. The tube is removed painlessly once the test is completed and the recording box analysed. Mr Hopkins will interpret the results from the physiology team in a follow-up clinic with you. The test measures levels of acid exposure time within the oesophagus, and sees if it correlates to your symptoms.

Barium Swallow

As an alternative to manometry, or if this did not give all the correct information, you can have a swallowing X-ray instead. Here, you drink a liquid containing an X-ray dye that enables live swallowing pictures to be taken. Again, Mr Hopkins will interpret the results from the swallowing X-ray in a follow-up clinic with you.

What Are the Treatment Options?

Lifestyle measures - commonly tried first:
  • Eat small regular meals, and avoid eating in the evening / at night.
  • Stop smoking, and reduce caffeine and alcoholic drinks.
  • Raise the head of the bed, and sleep on your right-hand side.
  • Exercise and maintain a healthy weight.
Medical treatment:
  • Over-the-counter antacids (Gaviscon or Rennie)
  • Prescribed Proton pump inhibitors (drugs ending in -prazole)
Surgical treatment:

Medical and lifestyle treatments can be very effective for some of the symptoms. Surgery is an option when:

  • Your clinical history agrees with the Endoscopy / Manometry / pH study findings. All patients considering hiatal surgery should have an upper GI endoscopy performed by a surgeon, as well as oesophageal manometry (or a barium study), and if needed pH studies, in order to confirm the diagnosis and assess the anatomy of the hiatus and stomach. AND:
  • Lifestyle and medical management together do not control all your symptoms, or:
  • You may not wish to take long-term medication or cannot tolerate these medicines, or:
  • Complications relating to reflux or the hiatus, e.g. prolonged oesophagus inflammation or a large hiatal defect.

What Does Hiatal Surgery Involve?

The aim of surgery is to restore or strengthen the normal anatomy at the hiatus, correcting any hiatal hernia and to reinforce the (faulty) valve at the junction between the gullet and stomach. This second part is the ‘fundoplication’ or ‘wrap’, stitching the top section of the stomach (fundus) over the front of the lower end of the gullet, to the hiatus muscles. The procedure normally takes less than 1.5 to 2 hours and takes effect immediately.

Before surgery:

Once we agree to go ahead with surgery, you will need to attend a pre-op assessment clinic, at which a number of routine checks and sometimes blood tests will be performed. You should do everything you can to maintain your health and fitness before an operation—we call this pre-habilitation. Smoking is strongly discouraged as it not only affects your breathing and the risk of anaesthetic problems, but can increase wound healing and infection problems. Improving your heart and lung fitness, with regular exercise, taking all your usual medications, and avoiding the risks of infections immediately before your operation is also advised. Regular vitamin and mineral supplements, especially if your diet can be variable, help make sure your body is ready for healing after surgery. Some patients may be asked to complete a special liver-reducing diet in the two weeks before surgery.

After surgery:

Some patients can be discharged on the same day as the operation (daycase), many stay overnight. You would be ready to be discharged if your pain is controlled with tablet painkillers, you can walk and you have eaten and passed urine. Anti-reflux medication can be reduced or stopped following surgery—depending on how much you take before surgery and Mr Hopkins will give you clear individual instructions.

All stitches are dissolvable. The glue or waterproof dressings used are suitable for the shower after 2 days, and can be removed or cleared after 7 days, but you should not soak in a bath for 7 days.

You will be advised to drink fluids only for the first 24 hours after surgery, before commencing a special diet for the following few weeks. Mr Hopkins will give you a diet sheet with clear advice on the stages of progression after surgery. Solid foods will be gradually reintroduced as surgery settles down.

Standard recovery takes 1–2 weeks after keyhole surgery, for driving and office work. Recovery after keyhole surgery for return to full activities including sport, exercise, gardening or DIY, and heavy lifting is up to 4 weeks. You should discuss your work or sporting activities with Mr Hopkins in clinic.

What Happens When I Go Home?

Pain: Paracetamol and ibuprofen, with occasional codeine or tramadol, should give adequate pain relief at home. I advise taking some regularly (i.e. 4–6 hourly) for the first 48 hours following surgery, then continued as required.
There may be some bruising at the operation site. This is entirely normal and will gradually go down. (If bleeding or swelling increases rapidly, within hours of surgery, you should seek medical attention.)

Mobility: This is very important. Try to remain normally active. If you feel tired, you should sit down and put your feet up for short periods, but you should not go to bed during the day. This is to improve circulation in your legs, and reduce the risk of blood clots occurring.

What Should I Watch Out For in the First Week Following Surgery?
  • Severe abdominal pain that does not go away with the painkillers prescribed
  • Major vomiting after the anaesthetic has worn off
  • Fever or flu-like symptoms associated with pain or vomiting
  • Significant redness/swelling at the surgical site
  • Calf pain or increasing breathlessness

If you experience any of these, it is important to seek medical attention as soon as possible, via the emergency department if needed, and it is important to tell everyone that you have had keyhole surgery.

What Are the Risks of Surgery?

Anti-reflux and hiatal surgery is a safely performed keyhole operation, but, like any type of surgery, there are risks:

Short term:
  • Shoulder tip pain – This is common after keyhole surgery and is due to gas used to inflate the abdomen during surgery. It normally resolves within 24–48 hours and is helped by walking around.
  • Bloating and/or flatulence – this can affect up to 1 in 3 patients where you may find it difficult to belch, and any swallowed air can therefore lead to bloating and in some patients this can lead to increased flatulence.
  • Dysphagia, or difficulty swallowing, is relatively common in the initial post-operative period but generally improves by 6–8 weeks as you progress through the diet stages. In rare circumstances, it may persist longer than 3–6 months and this would require further investigation or even intervention.
  • Infection – If occurs, this usually affects the small wounds, with signs of swelling or redness. This can be treated with tablet antibiotics. Very rarely, deeper internal infections can occur, and if you feel more unwell you should seek out urgent medical care.
  • Bleeding – can occur with any operation, if the cautery is dislodged, and occasionally may require a blood transfusion (unless you express a wish not to). Very occasionally it requires another operation to stop the bleeding or remove the blood clot. It is more common in patients taking blood thinning medicines.
  • Damage to nearby structures – this is very uncommon and would appear as a more serious deeper internal infection, and we would always check you out for this if there were any concerns about your recovery after surgery—with a swallowing x-ray.
  • Chest or breathing problems, cardiovascular problems if you have a history of this or clots in the legs or lungs (DVT or PE) is a risk of any keyhole operation, and while we do all we can to reduce these risks, they are never zero.
  • Recurrence – up to 20% of patients may develop recurrent symptoms such as heartburn or acid regurgitation in the future. Many patients take a smaller dose of PPI medication again, but still feel better having had the operation, and this is not regarded as a ‘failure of surgery’.

What Are the Differences for a Large Paraoesophageal Hiatus Hernia?

Surgery is more likely to be considered in those patients who can have more severe symptoms or where there is a risk of complications relating to the larger hiatus hernia. Surgery is still performed with advanced keyhole (laparoscopic) surgery by five tiny incisions, but the part of the operation to restore the normal anatomy at the diaphragm (hiatus) and reduce the stomach back into the abdomen, can take more time and be more difficult to perform. In some cases, the muscles of the hiatus are reinforced with a special mesh if Mr Hopkins thinks they are too weak during the operation. Again, the top section of the stomach (fundus) is usually wrapped around the lower end of the gullet to minimise reflux and fix the stomach within the abdomen, but sometimes this is felt not to be an advantage to the hiatal repair. The procedure normally takes 2 hours, but occasionally up to 4.

After surgery, the post-operative course is usually the same as for a normal anti-reflux operation, but Mr Hopkins will give you individual advice about your surgery, the recovery, and the post-operative diet. Occasionally, a few days’ stay is advised by the anaesthetist, or for complex hiatal surgery you may be required to stay in hospital until Mr Hopkins is happy your recovery is progressing. The risks of surgery are the same as above, but there is a higher rate of recurrence of the hiatal hernia or symptoms such as heartburn or regurgitation in the future.

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